RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
mir-326
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
In Silico Identification of miRNA Binding Sites; Measurement of Cytokines and Collagen Content etc.
Target
Tgf-beta1; Ets1
Pathway
NA
PubMed ID
Title
MicroRNA-326 Regulates Profibrotic Functions of Transforming Growth Factor-B in Pulmonary Fibrosis
Year
2014
Function
"Hsa-miR-326 regulates TGF-B1 expression and that hsa-miR-326 levels are inversely correlated to TGF-B1 protein levels in multiple human cell lines.MiR-326 was found to down-regulate profibrotic genes, such as Ets1, Smad3, and matrix metalloproteinase 9, whereas it up-regulates antifibrotic genes, such as Smad7."